500mg Berberine Supplement
60 Veg Capsules
Metabolic Gluten-Free Vegan Soy Free Dairy Free Wheat Free Corn Free Sugar-Free Capsules
Berberine is an active constituent of many plants including Phellodendron amurense root. Berberine activates adenosine monophosphate kinase (AMPK). AMPK is activated through various mechanisms including exercise to support glucose metabolism via an insulin-independent mechanism. Berberine has been the subject of human, randomized placebo-controlled trials.
These plants have been used in traditional Chinese and other herbal medicine systems for centuries. More recent characterization and isolation of the main active constituent, berberine, has led to the development of this Berberine hydrochloride supplement. Each capsule contains 500 mg berberine hcl.
Berberine supports healthy:
blood sugar metabolism and insulin metabolism*
cardiovascular function and lipid metabolism*
insulin receptor expression, with direct impact on supporting healthy glucose metabolism*
regulation of glycation*
For more info please read:
Berberine info sheet
More Information and Studies:
Berberine – A Powerful Supplement With Many Benefits
What Is Berberine?
Berberine is a compound that can be extracted from several different plants. It has a long history of use in traditional Chinese medicine.
How Does It Work?
Berberine has now been tested in hundreds of different studies.
It has been shown to have powerful effects on many different biological systems (3Trusted Source).
After you ingest berberine, it gets taken in by the body and transported into the bloodstream. Then it travels into the body’s cells.
Inside the cells, it binds to several different “molecular targets” and changes their function (4Trusted Source). This is similar to how pharmaceutical drugs work.
I am not going to get into much detail here, because the biological mechanisms are complicated and diverse.
However, one of the main actions of berberine is to activate an enzyme inside cells called AMP-activated protein kinase (AMPK) (5).
This enzyme is sometimes referred to as a “metabolic master switch” (6Trusted Source).
It is found in the cells of various organs, including the brain, muscle, kidney, heart and liver. This enzyme plays a major role in regulating metabolism (7Trusted Source, 8).
Berberine also affects various other molecules inside cells, and may even affect which genes are turned on or off (4Trusted Source).
Berberine affects the body at the molecular level, and has a variety of functions inside cells. One of the main functions is activating an important enzyme called AMPK, which regulates metabolism.
It Causes a Major Reduction in Blood Sugar Levels
Type 2 diabetes is a serious disease that has become incredibly common in recent decades, causing millions of deaths every year.
It is characterized by elevated blood sugar (glucose) levels, either caused by insulin resistance or lack of insulin.
Over time, high blood sugar levels can damage the body’s tissues and organs, leading to various health problems and a shortened lifespan.
Many studies show that berberine can significantly reduce blood sugar levels in individuals with type 2 diabetes (9Trusted Source).
In fact, its effectiveness is comparable to the popular diabetes drug metformin (Glucophage) (2Trusted Source, 10Trusted Source).
It seems to work via multiple different mechanisms (11Trusted Source):
Decreases insulin resistance, making the blood sugar lowering hormone insulin more effective.
Increases glycolysis, helping the body break down sugars inside cells.
Decrease sugar production in the liver.
Slows the breakdown of carbohydrates in the gut.
Increases the number of beneficial bacteria in the gut.
In one study of 116 diabetic patients, 1 gram of berberine per day lowered fasting blood sugar by 20%, from 7.0 to 5.6 mmol/L (126 to 101 mg/dL), or from diabetic to normal levels (12Trusted Source).
It also lowered hemoglobin A1c by 12% (a marker for long-term blood sugar levels), and also improved blood lipids like cholesterol and triglycerides (12Trusted Source).
According to a big review of 14 studies, berberine is as effective as oral diabetes drugs, including metformin, glipizide and rosiglitazone (13Trusted Source).
It works very well with lifestyle modifications, and also has additive effects when administered with other blood sugar lowering drugs (2Trusted Source).
If you look at discussions online, you often see people with sky-high blood sugars literally normalizing them just by taking this supplement.
This stuff really works, in both the studies and the real world.
Berberine is very effective at lowering blood sugar and HbA1c, which are elevated in people with diabetes. It works as well as some pharmaceutical drugs.
Berberine May Help You Lose Weight
Berberine may also be effective as a weight loss supplement.
So far, two studiesTrusted Source have examined the effects on body weight.
In a 12-week study in obese individuals, 500 mg taken three times per day caused about 5 pounds of weight loss, on average. The participants also lost 3.6% of their body fat (14).
Another more impressive study was conducted in 37 men and women with metabolic syndrome. This study went on for 3 months, and the participants took 300 mg, 3 times per day.
The participants dropped their body mass index (BMI) levels from 31.5 to 27.4, or from obese to overweight in only 3 months. They also lost belly fat and improved many health markers (15Trusted Source).
The researchers believe that the weight loss is caused by improved function of fat-regulating hormones, such as insulin, adiponectin and leptin.
Berberine also appears to inhibit the growth of fat cells at the molecular level (16Trusted Source, 17Trusted Source).
However, more research is needed on the weight loss effects of berberine.
Two studies have shown that berberine can cause significant weight loss, while improving all sorts of other health markers at the same time.
It Lowers Cholesterol and May Reduce Your Risk of Heart Disease
Heart disease is currently the world’s most common cause of premature death.
Many factors that can be measured in the blood are associated with an increased risk of heart disease.
As it turns out, berberine has been shown to improve many of these factors.
According to a review of 11 studies, it can (18Trusted Source):
It has also been shown to lower apolipoprotein B by 13-15%, which is a very important risk factor (19Trusted Source, 20Trusted Source).
According to some studies, berberine works by inhibiting an enzyme called PCSK9. This leads to more LDL being removed from the bloodstream (21Trusted Source, 22Trusted Source).
Keep in mind that diabetes, high blood sugar levels and obesity are also major risk factors for heart disease, all of which seem to be improved with this supplement.
Given the beneficial effects on all these risk factors, it seems likely that berberine could drastically reduce the risk of heart disease.
Studies show that berberine reduces cholesterol and triglyceride levels, while raising HDL (the “good”) cholesterol. It may lower the risk of heart disease in the long-term.
Berberine may also have numerous other health benefits:
Many of these benefits need more research before firm recommendations can be made, but the current evidence is very promising.
Preliminary studies show that berberine may have benefits against depression, cancer, infections, fatty liver and heart failure. It also has potent antioxidant and anti-inflammatory effects.
Dosage and Side Effects
Many of the studies cited in the article used dosages in the range of 900 to 1500 mg per day.
It is common to take 500 mg, 3 times per day, before meals (a total of 1500 mg per day).
Berberine has a half-life of several hours, so it is necessary to spread your dosage to several times per day to achieve stable blood levels.
If you have a medical condition or are on any medications, then it is recommended that you speak to your doctor before taking it.
This is especially important if you are currently taking blood sugar lowering medications.
Overall, berberine has an outstanding safety profile. The main side effects are related to digestion, and there are some reports of cramping, diarrhea, flatulence, constipation and stomach pain (10Trusted Source).
A common dosage recommendation is 500 mg, 3 times per day, half an hour before meals. Berberine may cause digestive side effects in some people.
Take Home Message
Berberine is one of very few supplements that are as effective as a drug.
It has powerful effects on various aspects of health, especially blood sugar control.
The people who stand to benefit the most are individuals with type 2 diabetes and metabolic syndrome.
However, it may also be useful as a general protection against chronic disease, as well as an anti-aging supplement.
If you use supplements, then berberine may be one of the top ones to include in your arsenal.
I’ve personally been taking it for a few weeks now, for general health improvement.
I plan to continue taking it, and I look forward to seeing more research on this promising health-promoting substance.
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