Blueberry Extract containing 45% Proanthocyanidin,
270 mg. 120 capsules
This is the ONLY Blueberry extract on the market today that
contains 45% Proanthocyanidin.
Proanthocyanidin (PA or PAC), also known as procyanidin, oligomeric proanthocyanidin (OPC), leukocyanidin, leucoanthocyanin and condensed tannins, is a class of flavanols. Proanthocyanidins are essentially polymer chains of flavonoids such as catechins. One was discovered in 1948 by Jacques Masquelier and called Vitamin P, although this name did not gain official category status and has since fallen out of usage. It was Masquelier who first developed techniques for the extraction of proanthocyanidins from certain plant species.
Proanthocyanidins have been sold as nutritional and therapeutic supplements in Europe since the 1980s. In contrast, the introduction of proanthocyanidins to the United States market has been relatively recent.
Proanthocyanidin Info Source WikiPedia
USDA Database for the Proanthocyanidin Content of Selected Foods
In studying longevity benefits of various compounds, scientists often use fruit flies as a laboratory model of aging. What researchers discovered is that fruit flies live 10% longer when fed a regular diet containing blueberry extract.5 Not only do the fruit flies live longer but they also show improved levels of physical activity. These enhancements arise both from increased tolerance of oxidant stress and from beneficial changes in the way certain important genes are expressed.
Still more dramatic life span extension has been shown in another aging model called C. elegans. After supplementation with blueberry extract, these organisms lived an average of 28% longer, and the maximum life span increased by 14%.6 The supplemented animals showed a 20% reduction in an age-related protein that impairs function, and vastly improved tolerance of stress in their environment.6
Mammals experience increased longevity and slowed aging processes when fed blueberry extracts, as shown by a study of mice on calorie restriction. When calorie-restricted mice had blueberry extracts added to their food ration, they not only outlived the normally-fed mice, but also the calorie-restricted mice who were not given the supplement as well.7
In addition to extending the life span of whole organisms, blueberries and their extracts slow aging in individual tissues, providing wide physiological benefits. (See table 1). Along with increasing all around longevity, blueberries can specifically decrease the risk of various degenerative diseases that reduce the human life spans.
Additional Scientific Studies for Blueberry Extract
Comments by Lloyd:
This is the only Blueberry extract on the market today that contains 45% Proanthocyanidin's.
If the blueberry extract you are taking does not say PROANTHOCYANIDIN on the label, it is not helping stop Hepatitis C.
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. While searching for new natural anti-HCV agents in agricultural products, we found a potent inhibitor of HCV RNA expression in extracts of blueberry leaves when examined in an HCV subgenomic replicon cell culture system.
This activity was observed in a methanol extract fraction of blueberry leaves and was purified by repeated fractionations in reversed-phase high-performance liquid chromatography. The final purified fraction showed a 63-fold increase in specific activity compared with the initial methanol extracts and was composed only of carbon, hydrogen, and oxygen. Liquid chromatography/mass-ion trap-time of flight analysis and butanol-HCl hydrolysis analysis of the purified fraction revealed that the blueberry leaf-derived inhibitor was proanthocyanidin.
Furthermore, structural analysis using acid thiolysis indicated that the mean degree of polymerization of the purified proanthocyanidin was 7.7, consisting predominantly of epicatechin. Proanthocyanidin with a polymerization degree of 8 to 9 showed the greatest potency at inhibiting the expression of subgenomic HCV RNA. Purified proanthocyanidin showed dose-dependent inhibition of expression of the neomycin-resistant gene and the NS-3 protein gene in the HCV subgenome in replicon cells.
While characterizing the mechanism by which proanthocyanidin inhibited HCV subgenome expression, we found that heterogeneous nuclear ribonucleoprotein A2/B1 showed affinity to blueberry leaf-derived proanthocyanidin and was indispensable for HCV subgenome expression in replicon cells. These data suggest that proanthocyanidin isolated from blueberry leaves may have potential usefulness as an anti-HCV compound by inhibiting viral replication.
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