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  • NatCell Immunity

NatCell Immunity


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Product Description

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Quantity - 24, 7 mL vials
This item is shipped Frozen

Each vial contains: 
Porcine thymus aqueous extract
Porcine liver aqueous extract (enriched with Mesenchyme 125x)
Porcine spleen aqueous extract (enriched with Mesenchyme 125x)

Natcell Product Info (.pdf)

Immunity as a key to aging

The immunological theory of aging arose from the fact that immune functions decline with age. Foreign antigens are progressively less well recognized while, on the opposite, increased reactivity toward auto-antigens is generally observed. Thymus involution is believed to play a major role in immune senescence. The thymus is a gland located in the upper part of the mediastinum, behind the sternum and above the heart. The thymus produces peptide factors that contribute to the maturation of T-lymphocytes first produced in the bone marrow. T-cells are responsible for identifying foreign antigens, boosting B cells to produce appropriate antibodies, stimulating phagocytosis and eliminating cancer cells as they appear. Moreover T-cells should do all these tasks while preserving the organism's healthy cells. A good healthy thymus is vital for the development of T-cells to their full bloom and particularly to get rid of the auto-reactive lymphocytes that form every now and then. Unfortunately, starting at puberty, as we grow older the thymus goes smaller. By age 30, the thymus gland has typically decreased its mass by two-thirds and its T-lymphocytes content by 90%. By age 60, functional thymic tissue has almost completely disappeared. Concomitantly, the level of thymic hormones declines in blood as we age (Iwata et al., 1981). The gradual loss of thymic functions leads to an increased susceptibility to infections, cancer and autoimmune diseases as we age (Goya et al, 2002).

Concomitantly with thymus involution, the nature of the T-lymphocyte response in the aging body progressively derives from a cellular-prone (Th1) to a humoral-prone (Th2) type. Upon activation and under the influence of specific factors called cytokines, T-helper cells differentiate into either Th1 or Th2 cells. Th1 cells provide cellular protection against invading pathogens such as bacteria or virus. They also activate other immune cells responsible for tracing and eliminating cancer cells as they form. An excessive Th1 response may lead to autoimmune diseases such as type I diabetes, multiple sclerosis or rheumatoid arthritis (among others). For their part, Th2 cells fight larger parasites by promoting the production of neutralizing antibodies. Overactive Th2 cells may cause allergic responses in predisposed individuals. Th1 and Th2 cells influence each other through the production of cytokines. An overactive Th1 response blunts the Th2 arm of immunity, and vice-versa.

A balanced Th1-Th2 immune responsiveness is a guarantee of good health. Unfortunately throughout life a number of events can affect the system. As an example, stress stimulates the production of cortisol, a hormone that favors Th2 response, making affected people more susceptible to viral infections. As mentioned above, age also impacts on the Th1-Th2 balance. In small children, as their immune system builds up, a Th2 type predominates. Middle-aged people tend to have a Th1 bias that switches again to a Th2 type in the elderly. As a consequence of this imbalance, aging people are more susceptible to infections such as influenza and pneumonia, old infections can be reactivated causing problems such as shingles or tuberculosis and cancer cells tend to escape immune surveillance more easily.

To thwart immune imbalance, dietary supplements containing thymus extract can be used. Thymus extract contains small peptides and other thymus-derived factors which help to restore and support an optimal immune balance. Thymic peptides and factors include thymopoietin, several thymosins, thymulin, thymostimulin, and thymic humoral factors. In vitro, thymus extract has the ability to stimulate maturation and differentiation of peripheral blood mononuclear cells (PBMC) in order to mount a full immune response and, in this aspect, is more powerful than Echinacea, a popular herb often used as an immunostimulant.

Clinically, thymus extract supplementation has been shown to be extremely effective in treating a wide variety of illnesses with impaired immunological functions as a common denominator (Walker, 1994; 1998). The pertinence of thymus extract supplementation in restoring immunocompetence in the elderly is supported by studies that examined different uses of thymic peptides. In a double-blind placebo-controlled clinical study, the deemed antibody response in older men was shown to be enhanced by augmentation with thymosin (Gravenstein et al., 1989). Similarly, thymopoietin, which is yet another thymic peptide, was shown to enhance the impaired lymphocyte stimulation in older people (Verhaegen et al., 1981). In another study, herpes zoster (shingles) was used as a clinical model to study the effects of thymus extract in 28 otherwise non immunocompromised patients. Results of this double blind study reported an accelerated rate of wound healing, shorter duration of vesicles, shorter time to first and crusting lesions, and a greater reduction of pain during the acute phase (Skotnicki 1989).

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An International Literature Review of Clinical Studies (HTML version)

An International Literature Review of Clinical Studies (PDF version)

A Novel Approach to Thymus (PDF)

Thymus Clinical Trials (PDF)

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